FASCINATION ABOUT CONOLIDINE ALKALOID FOR CHRONIC PAIN

Most not long ago, it's been identified that conolidine and the above derivatives act on the atypical chemokine receptor 3 (ACKR3. Expressed in very similar areas as classical opioid receptors, it binds to a big range of endogenous opioids. In contrast to most opioid receptors, this receptor acts to be a scavenger and isn't going to activate a 2nd